Interleukin 4 (IL-4) is an immunomodulatory cytokine thatfunctions to induce naïve helper T cells to differentiate intotype 2 T helper (Th2) cells. Th2 cells subsequently producemore IL-4 in a positive feedback loop. IL-4 also promotesimmunoglobulin IgG to IgE isotype switching on B cells. IL-4 binds the IL-4Rα receptor to activate STAT6 signaling.
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