Interleukin 17F (IL-17F) is one of six members of the IL-17family (IL-17A-F) secreted by activated CD4+ T cells andmonocytes. Similar to IL-17A, IL-17F binds to the IL17 RCreceptor and promotes the production of IL-6, IL-8, G-CSF andincreases matrix turnover rates. IL-17F is also thought toinhibit angiogenesis and induce endothelial cells to produceIL-2, MCP-1 and TGF-β1. Recombinant mouse IL-17F is anon-glycosylated, disulfide-linked homodimer, containing two 133amino acid chains, with a total molecular weight of 30 kDa.
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