BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Potentpositiveallostericmodulatorofα4β2nAChRs(EC50valuesare20and18nMforratandhuman,respectively).Selectiveforhα4β2overhα3β2,hα3β4andhα7.Inhibits(α4)2(β2)3,muscle-typeandTorpedonAChRs(IC50valuesare0.5,0.7and0.2μM,respectively),butnot(α4)3(β2)2receptors.ExhibitsABIlitytophotoincorporateintoaliphaticandnucleophilicaminoacidsidechains.
TechnicalData
| M.Wt | 379.28 |
| Formula | C18H19ClN4O.HCl |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| PubChemID | 127021040 |
| InChIKey | WNKFVIPYZXTQBR-UHFFFAOYSA-N |
| Smiles | CC1=C(C2=CC(C3=C(C=CC=C3)Cl)=NO2)C=NN1C4CCNCC4.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM |
|---|
| Solubility |
|---|
| water | 18.96 | 50 |
| DMSO | 37.93 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight379.28.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|
| 1mM | 2.64mL | 13.18mL | 26.37mL |
| 5mM | 0.53mL | 2.64mL | 5.27mL |
| 10mM | 0.26mL | 1.32mL | 2.64mL |
| 50mM | 0.05mL | 0.26mL | 0.53mL |
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