Tocris/NF 1819/5956/10/10 mg188bio精品生物—专注于实验室精品爆款的电商平台

BiologicalActivity

PotentandselectiveirreversibleMAGLinhibitor(IC₅₀valuesare0.25and7.4nMatrMAGLandhMAGL,respectively).Exhibits389-foldselectivityoverhFAAHandexhibitsminimalbindingatCBreceptors(IC₅₀>10μM).AlleviatessymptomsinaMSinvivomodel.Exhibitsanalgesiceffectsinanacuteinflammatorypainmodelinvivo.Amelioratesneuropathichypersensitivityinducedbyoxaliplatin(Cat.No.2623).DisplayshighmembranepermeABIlityandbrainpenetrant.

TechnicalData

M.Wt	463.46
Formula	C₂₄H₂₂FN₅O₄
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	1881244-28-5
Smiles	FC1=CC=C([C@@H]2[C@@H](C3=CC=C4OCOC4=C3)N(C2=O)C5CCN(C(N6C=NC=N6)=O)CC5)C=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	46.35	100
	ethanol	23.17	50

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight463.46.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.16mL	10.79mL	21.58mL
5mM	0.43mL	2.16mL	4.32mL
10mM	0.22mL	1.08mL	2.16mL
50mM	0.04mL	0.22mL	0.43mL

MolarityCalculator

Calculatethemass,volume,orconcentrationrequiredforasolution.

ReconstitutionCalculator

Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.

Volume(toaddtovial)

DilutionCalculator

Calculatethedilutionrequiredtoprepareastocksolution.