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HighaffinityandpotentcovalentEGFRkinaseinhibitor(Ki=0.14nM).InhibitsautophosphorylationofWTandmutantEGFRintumorcells(IC50valuesare5.8and6.6nM,respectively).
SoldforresearchpurposesunderagreementfromPfizerInc.
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Thefollowingdataisbasedontheproductmolecularweight372.78.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Referencesarepublicationsthatsupporttheproducts'biologicalactivity.
Schwartzetal(2014)CovalentEGFRinhibitoranalysisrevealsimportanceofreversIBLeinteractionstopotencyandmechanismsofdrugresistance.Proc.Natl.Acad.Sci.U.S.A.111173PMID:24347635
Keywords:PF6274484,supplier,PF6274484,epidermal,growth,factor,receptors,EGFR,kinase,inhibitors,inhibits,potent,high,affinity,covalent,EGFR,EGFR,TocrisBioscience
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