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Tocris/PBIT/5930/10/10 mg
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Tocris/PBIT/5930/10/10 mg

价格: ¥1260.00 市场价: 2100.00

货号: 5930/10
品牌: Tocris
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    • Description:JARID1(JumonjiAT-RichInteractiveDomain1)inhibitor
      ChemicalName:2-(4-Methylphenyl)-1,2-benzisothiazol-3(2H)-one
      Purity:≥98%(HPLC)
      BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

      BiologicalActivity

      JARID1(JumonjiAT-RichInteractiveDomain1)inhibitor(IC50valuesare3,4.9and6μMforJARID1B,1Aand1C,respectively).SelectiveforJARID1overUTXandJMJD3.IncreaseslevelsofmethylatedH3K4inJARIDB1-transfectedHeLacellsandMCF7cells.InhibitsproliferationofbreastcancercelllinesexpressinghighlevelsofJARIDB1.

      TechnicalData

      M.Wt241.31
      FormulaC14H11NOS
      StorageStoreat+4°C
      Purity≥98%(HPLC)
      CASNumber2514-30-9
      PubChemID935415
      InChIKeyKRXMYBAZKJBJAB-UHFFFAOYSA-N
      SmilesCC1=CC=C(N2SC3=C(C2=O)C=CC=C3)C=C1

      Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

      AllTocrisproductsareintendedforlaboratoryresearchuseonly.

      SolubilityData

      SolventMaxConc.mg/mLMaxConc.mM
      Solubility
      DMSO24.13100
      ethanol4.8320

      PreparingStockSolutions

      Thefollowingdataisbasedontheproductmolecularweight241.31.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

      Concentration/SolventVolume/Mass1mg5mg10mg
      1mM4.14mL20.72mL41.44mL
      5mM0.83mL4.14mL8.29mL
      10mM0.41mL2.07mL4.14mL
      50mM0.08mL0.41mL0.83mL

      ProductDatasheets

      CertificateofAnalysis/ProductDatasheet
      SafetyDatasheet

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