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JARID1(JumonjiAT-RichInteractiveDomain1)inhibitor(IC50valuesare3,4.9and6μMforJARID1B,1Aand1C,respectively).SelectiveforJARID1overUTXandJMJD3.IncreaseslevelsofmethylatedH3K4inJARIDB1-transfectedHeLacellsandMCF7cells.InhibitsproliferationofbreastcancercelllinesexpressinghighlevelsofJARIDB1.
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Thefollowingdataisbasedontheproductmolecularweight241.31.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Referencesarepublicationsthatsupporttheproducts'biologicalactivity.
Sayeghetal(2013)IdentificationofsmallmoleculeinhibitorsofJumonjiAT-richinteractivedomain1B(JARID1B)histonedemethylasebyasensitivehighthroughputscreen.J.Biol.Chem.2889408PMID:23408432
Keywords:PBIT,supplier,Jumonji,AT-Rich,Interactive,Domain,1,JARID1B,histone,lysine,demethylase,inhibitors,inhibits,breast,cancer,Histone,Demethylases,Histone,Demethylases,TocrisBioscience
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