Description:Potent,selectivehumantype15α-reductaseinhibitor
ChemicalName:(4aR,4bS,6aR,7R,9aS,9bS,10S,11aR)-7-[(1R)-1,5-Dimethylhexyl]hexadecahydro-1,4a,6a,10-tetramethyl-2H-indeno[5,4-f]quinolin-2-one
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Potentandselectivehumantype15α-reductaseinhibitor(5αR1,IC50=0.9nM).Exhibits100-foldselectivityfor5αR1over5αR2(IC50=154nM).Supresseshumanserumandsebumdihydrotestosterone(DHT)levelsinadose-dependentmannerwithoutaffectingsemenDHTconcentrations.Orallyactive.
TechnicalData
| M.Wt | 415.69 |
| Formula | C28H49NO |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 158493-17-5 |
| PubChemID | 178013 |
| InChIKey | XUTZDXHKQDPUMA-UHFFFAOYSA-N |
| Smiles | [H][C@]1([C@@H](CCCC(C)C)C)CC[C@]2([C@@]3([C@H](C[C@]4(N(C(CC[C@@]4([C@]3(CC[C@]12C)[H])C)=O)C)[H])C)[H])[H] |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM |
|---|
| Solubility |
|---|
| DMSO | 41.57 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight415.69.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|
| 1mM | 2.41mL | 12.03mL | 24.06mL |
| 5mM | 0.48mL | 2.41mL | 4.81mL |
| 10mM | 0.24mL | 1.2mL | 2.41mL |
| 50mM | 0.05mL | 0.24mL | 0.48mL |
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