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Tocris/Mitoglitazone/5799/50/50 mg

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货号: 5799/50

品牌: Tocris

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Description: Insulin sensitizer; exhibits low binding affinity at PPARγ

Alternative Names: CAY 10415, MSDC 0160

Chemical Name: 5-[[4-[2-(5-Ethyl-2-pyridinyl)-2-oxoethoxy]phenyl]methyl]-2,4-thiazolidinedione

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Insulin sensitizer; enhances insulin sensitivity and lowers blood-glucose levels in diabetic mouse models. Inhibits mitochondria pyruvate carriers; increases mitochondrial respiration rates, leading to a reduction in expression of lipogenic enzymes. Suppresses gluconeogenesis and lipogenesis in primary hepatocytes. Exhibits low binding affinity and activity at PPARγ (EC₅₀ = 23.7 μM).

Technical Data

M. Wt	370.42
Formula	C₁₉H₁₈N₂O₄S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	146062-49-9
PubChem ID	10429242
InChI Key	IRNJSRAGRIZIHD-UHFFFAOYSA-N
Smiles	CCC1=CC=C(C(COC2=CC=C(C=C2)CC3SC(NC3=O)=O)=O)N=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	37.04	100
	ethanol	7.41	20mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 370.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.7 mL	13.5 mL	27 mL
5 mM	0.54 mL	2.7 mL	5.4 mL
10 mM	0.27 mL	1.35 mL	2.7 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Divakaruni et al (2013) Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier. Proc.Natl.Acad.Sci.U.S.A. 110 5422 PMID: 23513224

Chen et al (2012) Insulin resistance and metabolic derangements in obese mice are ameliorated by a novel peroxisome proliferator-activated receptor γ-sparing thiazolidinedione. J.Biol.Chem. 287 23537 PMID: 22621923

Colca et al (2013) Identification of a mitochondrial target of thiazolidinedione insulin sensitizers (mTOT) relationship to newly identified mitochondrial pyruvate carrier proteins. PLoS One 8 e61551 PMID: 23690925

Keywords: Mitoglitazone, supplier, Antidiabetic, neurodegeneration, Alzheimer's, Parkinson's, diseases, mTOT, target, thiazolidinones, insulin, resistance, mitochondria, metabolism, pyruvate, carriers, MPC, hyperglycemia, CAY, 10415, MSDC, 0160, Insulin, and, insulin-like, Receptors, Insulin, and, Insulin-like, Receptors, Insulin, and, insulin-like, Receptors, Tocris Bioscience

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