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Acetyl-CoAcarboxylase(ACC)2and1inhibitor(IC50valuesare45and98nM,respectively).Reduceshepaticandskeletalmusclemalonyl-CoAlevelsinrats.Alsoinhibitshepaticdenovolipogenesisandreduceswholebodyrespiratoryexchangeratioinrats.Orallybioavailable.
SoldforresearchpurposesunderagreementfromPfizerInc.
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Thefollowingdataisbasedontheproductmolecularweight405.49.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Referencesarepublicationsthatsupporttheproducts'biologicalactivity.
Griffithetal(2014)Decreasingtherateofmetabolicketonereductioninthediscoveryofaclinicalacetyl-CoAcarboxylaseinhibitorforthetreatmentofdiabetes.J.Med.Chem.5710512PMID:25423286
Keywords:PF05175157,supplier,PF05175157,Acetyl,CoA,carboxylase,1,2,inhibitors,inhibits,ACC1,ACC2,orally,bioavailable,type,2,diabetes,mellitus,Other,Ligases,Other,Lipid,Metabolism,Other,Lipid,Metabolism,TocrisBioscience
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