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Tocris/PF 05175157/5790/10/10 mg
  • Tocris/PF 05175157/5790/10/10 mg

Tocris/PF 05175157/5790/10/10 mg

价格: ¥1788.00 市场价: 2980.00

货号: 5790/10
品牌: Tocris
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    • Description:Acetyl-CoAcarboxylase(ACC)1and2inhibitor
      ChemicalName:1,4-Dihydro-1'-[2-methyl-1H-benzimidazol-6-yl)carbonyl]-1-(1-methylethyl)-spiro[5H-indazole-5,4'-piperidin]-7(6H)-one
      Purity:≥98%(HPLC)
      BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

      BiologicalActivity

      Acetyl-CoAcarboxylase(ACC)2and1inhibitor(IC50valuesare45and98nM,respectively).Reduceshepaticandskeletalmusclemalonyl-CoAlevelsinrats.Alsoinhibitshepaticdenovolipogenesisandreduceswholebodyrespiratoryexchangeratioinrats.Orallybioavailable.

      LicensingInformation

      SoldforresearchpurposesunderagreementfromPfizerInc.

      TechnicalData

      M.Wt405.49
      FormulaC23H27N5O2
      StorageStoreat+4°C
      Purity≥98%(HPLC)
      CASNumber1301214-47-0
      PubChemID52934180
      InChIKeyBDXXSFOJPYSYOC-UHFFFAOYSA-N
      SmilesO=C(C4=CC=C(N=C(C)N5)C5=C4)N1CCC(CC(C=NN3C(C)C)=C3C(C2)=O)2CC1

      Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

      AllTocrisproductsareintendedforlaboratoryresearchuseonly.

      SolubilityData

      SolventMaxConc.mg/mLMaxConc.mM
      Solubility
      DMSO20.2750
      ethanol8.1120

      PreparingStockSolutions

      Thefollowingdataisbasedontheproductmolecularweight405.49.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

      Concentration/SolventVolume/Mass1mg5mg10mg
      1mM2.47mL12.33mL24.66mL
      5mM0.49mL2.47mL4.93mL
      10mM0.25mL1.23mL2.47mL
      50mM0.05mL0.25mL0.49mL

      ProductDatasheets

      CertificateofAnalysis/ProductDatasheet
      SafetyDatasheet

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