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Tocris/MDNI-caged-L-glutamate/5785/10/10 mg

价格: ¥3468.00 市场价: 5780.00

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货号: 5785/10

品牌: Tocris

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Description: Stable photoreleaser of L-glutamate

Alternative Names: caged MDNI glutamate, DNI glutamate, DNI-GLU

Chemical Name: (S)-α-Amino-2,3-dihydro-4-methoxy-5,7-dinitro-δ-oxo-1H-indole-1-pentanoic acid

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Rapidly and efficiently releases glutamate (Cat. No. 0218) when photolysed (350 - 365 nm excitation). Water soluble and stable at neutral pH, and pharmacologically inactive at neuronal glutamate receptors (up to 200 μM). 5.5 times more photosensitive than MNI-caged L-glutamate (Cat. No. 1490). Laser activation of MDNI-glu evokes a rapid increase in intracellular Ca²⁺ concentration in astrocytes.

Technical Data

M. Wt	368.3
Formula	C₁₄H₁₆N₄O₈
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	864085-92-7
PubChem ID	124221751
InChI Key	SYNWQVVPBORTQE-QMMMGPOBSA-N
Smiles	O=C(CC[C@H](N)C(O)=O)N1C2=C([N+]([O-])=O)C=C([N+]([O-])=O)C(OC)=C2CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	3.68	10mM with gentle warming
	DMSO	18.41	50

Preparing Stock Solutions

The following data is based on the product molecular weight 368.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.72 mL	13.58 mL	27.15 mL
5 mM	0.54 mL	2.72 mL	5.43 mL
10 mM	0.27 mL	1.36 mL	2.72 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Fedoryak et al (2005) Synthesis of a caged glutamate for efficient one- and two-photon photorelease on living cells. Chem. Commun. (Camb.) 7 3664 PMID: 16027904

Papageorgiou et al (2005) Synthetic and photochemical studies of substituted 1-acyl-7-nitroindolines. Photochem.Photobiol.Sci. 4 887 PMID: 16252044

Popovic et al (2015) Electrical behaviour of dendritic spines as revealed by voltage imaging. Nat.Commun. 6 8436 PMID: 26436431

Keywords: MDNI-caged-L-glutamate, supplier, Stable, photoreleaser, L-glutamate, Caged, Compounds, Glutamate, mGlur, Receptors, Metabotropic, Non-Selective, iGlur, Ionotropic, agonists, MNI, glutamate, MNI-Glutamate, caged, MDNI, glutamate, DNI, glutamate, DNI-GLU, Miscellaneous, Glutamate, Non-selective, Ionotropic, Glutamate, Non-selective, mGlu, Caged, Glutamate, Compounds, Miscellaneous, Glutamate, Tocris Bioscience

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