Biological Activity
Technical Data
Solubility
Calculators
Datasheets
References
Biological Activity
Indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50 = 7 μM); disrupts tryptophan catabolism. Enhances the antitumor and antiviral immunoresponses of CD8+ T-cells in vitro. Reduces tumor volume in mice with xenografts overexpressing IDO.
Technical Data
M. Wt
218.25
Formula
C12H14N2O2
Storage
Store at -20°C
Purity
≥97% (HPLC)
CAS Number
110117-83-4
PubChem ID
405012
InChI Key
ZADWXFSZEAPBJS-SNVBAGLBSA-N
Smiles
CN1C=C(C[C@H](C(O)=O)N)C2=CC=CC=C21
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
Solvent
Max Conc. mg/mL
Max Conc. mM
Solubility
water
1.09
5mM with gentle warming
Preparing Stock Solutions
The following data is based on the product molecular weight 218.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass
1 mg
5 mg
10 mg
1 mM
4.58 mL
22.91 mL
45.82 mL
5 mM
0.92 mL
4.58 mL
9.16 mL
10 mM
0.46 mL
2.29 mL
4.58 mL
50 mM
0.09 mL
0.46 mL
0.92 mL
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Product Datasheets
Certificate of Analysis / Product Datasheet
Safety Datasheet
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References
References are publications that support the products' biological activity.
Nakamuraet al (2015) Effects of indoleamine 2,3-dioxygenase inhibitor in non-Hodgkin lymphoma model mice. Int.J.Hematol. 102 327 PMID: 26243621
Rytelewskiet al (2014) Suppression of immunodominant antitumor and antiviral CD8+ T cell responses by indoleamine 2,3-dioxygenase. PLoS One 9 e90439 PMID: 24587363