BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Naloxoneconjugate.FollowingoraladmiNISTrationinducesdelayeddiarrhea,aswellasmilderanddelayedwithdrawalbehaviorandtailskintemperature(TST)responsecomparedwithnaloxoneinmorphine-dependentrats.
TechnicalData
| M.Wt | 565.52 |
| Formula | C25H29NO10.H2CO3 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| PubChemID | 121513881 |
| InChIKey | JWCWXAGEJDGZRX-IDUKCLALSA-N |
| Smiles | O=C(O)O.O=C3[C@H]5[C@]26C1=C(O5)C(OC4OC(C(O)=O)C(O)C(O)C4O)=CC=C1C[C@@H](N(CC6)CC=C)[C@@](O)2CC3 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM |
|---|
| Solubility |
|---|
| DMSO | 56.55 | 100 |
| water | 56.55 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight565.52.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|
| 1mM | 1.77mL | 8.84mL | 17.68mL |
| 5mM | 0.35mL | 1.77mL | 3.54mL |
| 10mM | 0.18mL | 0.88mL | 1.77mL |
| 50mM | 0.04mL | 0.18mL | 0.35mL |
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