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当前位置： Tocris >>> Tocris/AR-C 141990 hydrochloride/5658/1/1 mg

Tocris/AR-C 141990 hydrochloride/5658/1/1 mg

Tocris/AR-C 141990 hydrochloride/5658/1/1 mg

价格: ¥2820.00 市场价: 4700.00

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货号: 5658

品牌: Tocris

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- Description:MCT1inhibitor
  ChemicalName:5-[[(3R)-3-Hydroxy-1-pyrrolidinyl]carbonyl]-3-methyl-1-(2-methylpropyl)-6-(4-quinolinylmethyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione
  Purity:≥98%(HPLC)
  BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
  BiologicalActivity
  Monocarboxylatetransporter(MCT1)inhibitor(pK_i=7.6.Exhibitsapproximately10-foldselectivityforMCT1overMCT2andnosignificantactivityagainstMCT3or4.Inhibitsgraftversushostresponseandprolongscardiacgraftsurvivalinaratmodel.Immunosuppressant.AlsoinhibitsbrainpenetrationofGHBanalogHOCPCA.
  TechnicalData
  M.Wt 529.05
  Formula C₂₆H₂₈N₄O₄S.HCl
  Storage Storeat-20°C
  Purity ≥98%(HPLC)
  Smiles O=C(N1C[C@H](O)CC1)C2=C(CC3=C4C(C=CC=C4)=NC=C3)SC(N5CC(C)C)=C2C(N(C)C5=O)=O.Cl
  Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
  AllTocrisproductsareintendedforlaboratoryresearchuseonly.
  SolubilityData
  Solvent MaxConc.mg/mL MaxConc.mM
  Solubility
  DMSO 49.26 100
  ethanol 49.26 100
  water 49.26 100
  PreparingStockSolutions
  Thefollowingdataisbasedontheproductmolecularweight529.05.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
  Concentration/SolventVolume/Mass 1mg 5mg 10mg
  1mM 1.89mL 9.45mL 18.9mL
  5mM 0.38mL 1.89mL 3.78mL
  10mM 0.19mL 0.95mL 1.89mL
  50mM 0.04mL 0.19mL 0.38mL