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PotentandselectiveNUAK1inhibitor(IC50=100nM).Exhibitsnosignificantinhibitionagainstapanelof139kinases,includingtenAMPKfamilymembers.InhibitsNUAK1-mediatedMYPT1phosphorylation.AlsoinhibitscellproliferationinU2OScellsinvitro,toasimilarextentasNUAK1knockdownmodels.
SoldunderlicensefromDana-FarberCancerInstitute
HTH01-015isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxII.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Thefollowingdataisbasedontheproductmolecularweight468.55.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Referencesarepublicationsthatsupporttheproducts'biologicalactivity.
Banerjeeetal(2014)CharacterizationofWZ4003andHTH-01-015asselectiveinhibitorsoftheLKB1-tumour-suppressor-activatedNUAKkinases.BiochemJ.457215PMID:24171924
Keywords:HTH01-015,supplier,HTH01-015,potent,selective,NUAK1,family,SNF1-like,kinase-1,inhibitors,inhibits,NUAK,NUAK,TocrisBioscience
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