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TypeIBMPreceptorinhibitor(Kivaluesare<1,5.4and43nMforALK6,ALK3andALK2,respectively).Exhibits>30-foldselectivityoverALK4,ALK5,BMPR2,AMPKandVEGFR2.AlsobindstoTGFBR2(Ki=85nM).DecreasesgrowthandinducescelldeathofH1299non-smallcelllungcarcinomacellsinvitro.Enhancesliverregenerationinvivo.
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Thefollowingdataisbasedontheproductmolecularweight451.52.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Referencesarepublicationsthatsupporttheproducts'biologicalactivity.
Tsugawaetal(2014)Specificactivinreceptor-likekinase3inhibitorsenhanceliverregeneration.J.Pharmacol.Exp.Ther.351549PMID:25271257
Keywords:DMH2,supplier,Type-1,BMP,bone,morphogenetic,protein,receptors,inhibitors,inhibits,ALK6,ALK2,ALK3,BMP,and,Other,Activin,Receptors,BMP,and,Other,Activin,Receptors,TocrisBioscience
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