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Highaffinity,selectiveANPclearancereceptor(NPR3)antagonist(Ki=0.45nM).Exhibits>20,000-foldselectivityforNPR3overNPR1.InhibitsANP-stimulatedNa+/K+pumpactivityinrabbitventricularcardiomyocytesinvitro.AlsoblocksproliferationofrodentneonatalcardiomyocytesseenatlowANPconcentrationsinvitro.
| M.Wt | 915.1 |
| Formula | C46H66N12O8 |
| Sequence | RIDR (Modifications:Arg-1=N2-[4-(2-Naphthoylamino)phenylacetyl],Arg-4=C-terminal(S)-2-methylbutylamide) |
| Storage | Storeat-20°C |
| CASNumber | 124833-45-0 |
| PubChemID | 44301714 |
| InChIKey | UNMJSSQZDQBGDS-OCFLPWLCSA-N |
| Smiles | CC[C@H](C)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CC1=CC=C(NC(=O)C2=CC3=C(C=CC=C3)C=C2)C=C1)[C@@H](C)CC |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solubility | Solubleto1mg/mlinwater |
Thefollowingdataisbasedontheproductmolecularweight915.1.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.09mL | 5.46mL | 10.93mL |
| 5mM | 0.22mL | 1.09mL | 2.19mL |
| 10mM | 0.11mL | 0.55mL | 1.09mL |
| 50mM | 0.02mL | 0.11mL | 0.22mL |
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