Description:Inhibitorofactinpolymerization
ChemicalName:(3E,5R,9R,11E,12aS,13S,15S,15aS,16S,18aS)-6,7,8,9,10,12a,13,14,15,15a,16,17-Dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-16-(phenylmethyl)-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Inhibitorofactinpolymerization.Inhibitscelldivision,migrationandglucosetransport.CausesG2/McellcyclearrestandapoptosisinHCT-116colorectalcarcinomacells.Cellpermeable.
TechnicalData
| M.Wt | 479.61 |
| Formula | C29H37NO5 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 14930-96-2 |
| PubChemID | 5311281 |
| InChIKey | GBOGMAARMMDZGR-TYHYBEHESA-N |
| Smiles | C=C([C@H]1C)[C@@H](O)[C@]([C@@]2(O3)[C@]1([H])[C@H](CC4=CC=CC=C4)NC2=O)([H])/C=C/C[C@H](C)CCC[C@@H](O)/C=C/C3=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM |
|---|
| Solubility |
|---|
| DMSO | 4.8 | 10mMwithgentlewarming |
| ethanol | 9.59 | 20 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight479.61.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|
| 1mM | 2.09mL | 10.43mL | 20.85mL |
| 5mM | 0.42mL | 2.09mL | 4.17mL |
| 10mM | 0.21mL | 1.04mL | 2.09mL |
| 50mM | 0.04mL | 0.21mL | 0.42mL |
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
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