BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
PhotoswitchableTRPV1channelblocker(IC50=3.1μM).ActsasanantagoNISTintransconformationduringvoltagegatedactivation.Alsoactsasanantagonistinthecisformationduringcapsaicin-inducedTRPV1currents.Switchesconformationfromcistotransat440nmandtranstocisat360nm.Allowsphotoswitchableantagonistandanagonisttobeappliedatthesametime.
TechnicalData
| M.Wt | 514.56 |
| Formula | C26H25F3N4O2S |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1459809-09-6 |
| PubChemID | 121513863 |
| InChIKey | COPZFJSJZPCWFD-UHFFFAOYSA-N |
| Smiles | S=C(NCCC3=CC=C(/N=N/C4=CC=C(C(F)(F)F)C=C4)C=C3)N(CCC2)CC1=C2C=C(O)C(O)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM |
|---|
| Solubility |
|---|
| DMSO | 51.46 | 100 |
| water | 10.29 | 20mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight514.56.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|
| 1mM | 1.94mL | 9.72mL | 19.43mL |
| 5mM | 0.39mL | 1.94mL | 3.89mL |
| 10mM | 0.19mL | 0.97mL | 1.94mL |
| 50mM | 0.04mL | 0.19mL | 0.39mL |
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