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Tocris/Clemizole hydrochloride/5371/10/10 mg

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货号: 5371/10

品牌: Tocris

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Description: TRPC5 blocker; also H₁ antagonist

Chemical Name: 1-[(4-Chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-1H-benzimidazole hydrochloride

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

TRPC5 channel blocker (IC₅₀ values are 1.1, 6.4, 9.1, 11.3 and 26.5 μM for TRPC5, TRPC4, TRPC3, TRPC6 and TRPC7 respectively). Exhibits minimal effect on TRPM3, TRPM8 and TRPV1-4 channels. Also histamine H₁ receptor antagonist and anticonvulsant in zebrafish Dravet syndrome model.

Compound Libraries

Clemizole hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	362.3
Formula	C₁₉H₂₀ClN₃. HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	1163-36-6
PubChem ID	14412
InChI Key	DNFMJYXRIMLMBZ-UHFFFAOYSA-N
Smiles	ClC(C=C4)=CC=C4CN2C(CN3CCCC3)=NC1=CC=CC=C12.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	18.11	50
	water	7.25	20

Preparing Stock Solutions

The following data is based on the product molecular weight 362.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.76 mL	13.8 mL	27.6 mL
5 mM	0.55 mL	2.76 mL	5.52 mL
10 mM	0.28 mL	1.38 mL	2.76 mL
50 mM	0.06 mL	0.28 mL	0.55 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Aguilar et al (1986) Pharmacological investigation into the effects of histamine and histamine analogues on guinea-pig and rat colon in vitro. Br.J.Pharmacol. 88 501 PMID: 3742147

Richter et al (2014) Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5. Mol.Pharm. 86 514 PMID: 25140002

Baraban et al (2013) Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. Nat.Commun. 4 2410 PMID: 24002024

Keywords: Clemizole hydrochloride, supplier, transient, potential, channels, TRPC5, histamine, receptors, blockers, antagonists, TRPC, Histamine, H1, Receptors, TRPC, Tocris Bioscience

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