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Tocris/Rosiglitazone/5325/10/10 mg

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货号: 5325/10

品牌: Tocris

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Description: Potent and selective PPARγ agonist; antidiabetic agent.

Alternative Names: BRL 49653

Chemical Name: 5-[[4-[2-(Methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent and selective PPARγ agonist (EC₅₀ = 60 nM); exhibits no activity at PPARα and PPARβ. Promotes differentiation of pluripotent C3H10T1/2 stem cells into adipocytes. Exhibits antihyperglycemic activity in diabetic ob/ob mouse model. Antidiabetic agent.

Compound Libraries

Rosiglitazone is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	357.43
Formula	C₁₈H₁₉N₃O₃S
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	122320-73-4
PubChem ID	77999
InChI Key	YASAKCUCGLMORW-UHFFFAOYSA-N
Smiles	CN(CCOC1=CC=C(CC2SC(NC2=O)=O)C=C1)C3=CC=CC=N3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	1eq. HCl	35.74	100
	DMSO	35.74	100

Preparing Stock Solutions

The following data is based on the product molecular weight 357.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.8 mL	13.99 mL	27.98 mL
5 mM	0.56 mL	2.8 mL	5.6 mL
10 mM	0.28 mL	1.4 mL	2.8 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Lehmann et al (1995) An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma). J.Biol.Chem. 270 12953 PMID: 7768881

Willson et al (1996) The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones. J.Med.Chem. 39 665 PMID: 8576907

Keywords: Rosiglitazone, supplier, BRL49653, High, affinity, selective, PPAR, agonist, thiazolidinedione, TZD, derivative, antidiabetic, agent, BRL, 49653, PPARgamma, Receptors, Other, Differentiation, Products, PPARgamma, Receptors, Tocris Bioscience

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