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Tocris/WWL 123/5317/50/50 mg

价格: ¥9180.00 市场价: 15300.00

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货号: 5317/50

品牌: Tocris

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Description: α/β-hydrolase domain 6 (ABHD6) inhibitor; antiepileptic

Chemical Name: N-[[1,1'-Biphenyl]-3-ylmethyl)-N-methylcarbamic acid 4'-(aminocarbonyl)[1,1'-biphenyl]-4-yl ester

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

α/β-hydrolase domain 6 (ABHD6) inhibitor (IC₅₀ = 0.43 μM). Blocks PTZ-induced seizures in healthy mice and spontaneous seizures in R6/2 mice. Antiepileptic activity is independent of CB₁ and CB₂ receptors, but is GABA_A receptor dependent. Brain penetrant.

Other Information

There appears to be some confusion about the structure of WWL 123. Tocris sells N-[[1,1'-Biphenyl]-3-ylmethyl)-N-methylcarbamic acid 4'-(aminocarbonyl)[1,1'-biphenyl]-4-yl ester [1338574-83-6], which has been confirmed by the inventor, Prof B. Cravatt, as the correct compound. Other vendors sell the corresponding 3-yl regioisomer [1338575-41-9], which is the incorrect compound.

Compound Libraries

WWL 123 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	436.5
Formula	C₂₈H₂₄N₂O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1338574-83-6
PubChem ID	90209976
InChI Key	UUJGYRHAOHORFC-UHFFFAOYSA-N
Smiles	NC(C1=CC=C(C2=CC=C(OC(N(C)CC3=CC(C4=CC=CC=C4)=CC=C3)=O)C=C2)C=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	43.65	100

Preparing Stock Solutions

The following data is based on the product molecular weight 436.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.29 mL	11.45 mL	22.91 mL
5 mM	0.46 mL	2.29 mL	4.58 mL
10 mM	0.23 mL	1.15 mL	2.29 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Naydenov et al (2014) ABHD6 blockade exerts antiepileptic activity in PTZ-induced seizures and in spontaneous seizures in R6/2 mice. Neuron 83 361 PMID: 25033180

Keywords: WWL 123, supplier, WWL123, epilepsy, antiepileptics, anticonvulsants, alpha, beta, hydrolase, domain, 6, ABHD6, GABAA, α, β, ahydrolase, alphahydrolase, inhibits, inhibitors, Other, Hydrolases, Other, Hydrolases, Tocris Bioscience

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