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Tocris/trans-ISRIB/5284/10/10 mg

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货号: 5284/10

品牌: Tocris

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Description: Integrated stress response (ISR) inhibitor

Chemical Name: N,N'-trans-1,4-cyclohexanediylbis[2-(4-chlorophenoxy)acetamide]

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Integrated stress response (ISR) inhibitor; reverses the effects of eIF2α phosphorylation (IC₅₀ = 5 nM) and restores cell translation capacity. Acts downstream of PERK, targeting interactions between eIF2α kinases and elF2B. Blocks ATF4 production without altering the IRE1 or ATF6 responses in vitro. Displays memory enhancement in hippocampus-dependent spatial and fear-associated learning in rodents. Brain penetrant.

Technical Data

M. Wt	451.34
Formula	C₂₂H₂₄Cl₂N₂O₄
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	1597403-47-8
PubChem ID	1011240
InChI Key	HJGMCDHQPXTGAV-UHFFFAOYSA-N
Smiles	O=C(COC1=CC=C(Cl)C=C1)N[C@@H]2CC[C@@H](NC(COC3=CC=C(Cl)C=C3)=O)CC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	4.51	10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 451.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.22 mL	11.08 mL	22.16 mL
5 mM	0.44 mL	2.22 mL	4.43 mL
10 mM	0.22 mL	1.11 mL	2.22 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Sidrauski et al (2013) Pharmacological brake-release of mRNA translation enhances cognitive memory. Elife 2 e00498 PMID: 23741617

Sekine et al (2015) Stress responses. Mutations in a translation initiation factor identify the target of a memory-enhancing compound. Science 348 1027 PMID: 25858979

Hinnebusch (2015) Cell biology. Blocking stress response for better memory? Science 348 967 PMID: 26023119

Keywords: trans-ISRIB, supplier, Potent, inhibitors, inhibits, of, PERK, signaling, UPR, unfolded, protein, response, endoplasmic, reticulum, ER, stress, memory, consolidation, eIF2, alpha, kinases, ISR, integrated, stress, response, DNA,, RNA, and, Protein, Synthesis, Miscellaneous, Compounds, PERK, Other, ER, stress/UPR, PERK, Tocris Bioscience

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