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Tocris/Ramipril/5250/50/50 mg

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货号: 5250/50

品牌: Tocris

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Description: Non-peptide, competitive angiotensin-converting enzyme (ACE) inhibitor

Chemical Name: (2S,3aS,6aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Non-peptide, competitive angiotensin converting enzyme (ACE) inhibitor (IC₅₀ = 5 nM). Prodrug which is hydrolyzed in vivo to the active metabolite ramiprilat. Displays protective effects on endothelium against high-glucose induced dysfunction. Exhibits antihypertensive effects.

Compound Libraries

Ramipril is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	416.51
Formula	C₂₃H₃₂N₂O₅
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	87333-19-5
PubChem ID	5362129
InChI Key	HDACQVRGBOVJII-JBDAPHQKSA-N
Smiles	[H][C@@]12CCC[C@@]([H])1N(C([C@H](C)N[C@H]([C@@](OCC)=O)CCC3=CC=CC=C3)=O)[C@H]([C@@](O)=O)C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	41.65	100
	ethanol	41.65	100

Preparing Stock Solutions

The following data is based on the product molecular weight 416.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.4 mL	12 mL	24.01 mL
5 mM	0.48 mL	2.4 mL	4.8 mL
10 mM	0.24 mL	1.2 mL	2.4 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Tian et al (2014) Ramipril protects the endothelium from high glucose-induced dysfunction through CaMKK beta /AMPK and heme oxygenase-1 activation. J.Pharmacol.Exp.Ther. 350 5 PMID: 24741076

Levitt et al (2006) Human physiologically based pharmacokinetic model for ACE inhibitors: ramipril and ramiprilat. BMC Clin. Pharmacol. 6 1 PMID: 16398929

Stevens et al (1988) Ramipril inhibition of rabbit (Oryctolagus cuniculus) small intestinal brush border membrane angiotensin converting enzyme. Comp.Biochem.Physiol C. 91 493 PMID: 2905962

Keywords: Ramipril, supplier, Non-peptide, competitive, angiotensin, converting, enzyme, ACE, inhibitors, inhibits, antihypertensive, Angiotensin-Converting, Enzyme, Angiotensin-Converting, Enzyme, Tocris Bioscience

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