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Tocris/NVP ADW 742/5247/10/10 mg

价格: ¥3060.00 市场价: 5100.00

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货号: 5247/10

品牌: Tocris

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Description: ATP-competitive inhibitor of IGF1R

Chemical Name: 5-[3-(Phenylmethoxy)phenyl]-7-[trans-3-(1-pyrrolidinylmethyl)cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

ATP-competitive inhibitor of IGF1R (IC₅₀ in the range of 0.1-0.2 μM). Also inhibits c-Kit kinase activity (IC₅₀ in the range of 3-5 μM). Exhibits a synergistic effect with Imatinib, enhancing the sensitivity of multiple small cell lung cancer cell lines to the chemotherapeutics etoposide (Cat. No. 1226) and carboplatin (Cat. No. 2626).

Compound Libraries

NVP ADW 742 is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox II. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	453.58
Formula	C₂₈H₃₁N₅O
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	475488-23-4
PubChem ID	9825149
InChI Key	LSFLAQVDISHMNB-UHFFFAOYSA-N
Smiles	NC1=NC=NC2=C1C(C4=CC(OCC5=CC=CC=C5)=CC=C4)=CN2[C@@H]3C[C@@H](CN6CCCC6)C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	22.68	50
	ethanol	4.54	10

Preparing Stock Solutions

The following data is based on the product molecular weight 453.58. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.2 mL	11.02 mL	22.05 mL
5 mM	0.44 mL	2.2 mL	4.41 mL
10 mM	0.22 mL	1.1 mL	2.2 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Warshamana-Greene et al (2005) The insulin-like growth factor-I receptor kinase inhibitor, NVP-ADW742, sensitizes small cell lung cancer cell lines to the effects of chemotherapy. Clin.Cancer Res. 11 1563 PMID: 15746061

Warshamana-Greene et al (2004) The insulin-like growth factor-I (IGF-I) receptor kinase inhibitor NVP-ADW742, in combination with STI571, delineates a spectrum of dependence of small cell lung cancer on IGF-I and stem cell factor signaling. Mol.Cancer Ther. 3 527 PMID: 15141010

Zhou et al (2011) The insulin-like growth factor-I receptor kinase inhibitor NVP-ADW742 sensitizes medulloblastoma to the effects of chemotherapy. Oncol. Rep. 25 1565 PMID: 21455580

Keywords: NVP ADW 742, supplier, NVPADW742, ATP, competitive, inhibitors, inhibits, of, IGF1, receptors, kinases, c-Kit, small, cell, lung, cancer, cell, lines, SCLC, insulin-like, growth, factor-1, receptor, Insulin, and, insulin-like, Receptors, Insulin, and, Insulin-like, Receptors, Insulin, and, insulin-like, Receptors, Tocris Bioscience

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