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Tocris/CC4/5236/50/50 mg

价格: ¥7740.00 市场价: 12900.00

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货号: 5236/50

品牌: Tocris

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Description: High affinity and subtype-selective α6β2 and α4β2 partial agonist

Chemical Name: (1R,5S)-1,2,3,4,5,6-Hexahydro-3-[2-[(1R,5S)-1,5,6,8-tetrahydro-8-oxo-1,5-methano-2H-pyrido[1,2-a][1,5]diazocin-3(4H)-yl]ethyl]-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

High affinity and subtype selective α6β2 and α4β2 partial agonist (K_i values are 12 and 26nM for rat α6β2 and α4β2 receptors respectively). Has low affinity for α3β4 and α7 receptors (K_i values are 4.8 and 13 μM for human α3β4 and rat α7 receptors respectively). Stimulates dopamine release from striatal slices in vitro. Attenuates nicotine-induced self-administration and conditional place preference in rats.

Compound Libraries

CC4 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	406.52
Formula	C₂₄H₃₀N₄O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	492-02-4
PubChem ID	91654624
InChI Key	LEXDAVFCJPDCNA-VNTMZGSJSA-N
Smiles	O=C1N2C([C@@](C3)([H])CN(CCN5C[C@](C6)([H])C(N4C[C@]6([H])C5)=CC=CC4=O)C[C@@]3([H])C2)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	40.65	100
	water	8.13	20

Preparing Stock Solutions

The following data is based on the product molecular weight 406.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.46 mL	12.3 mL	24.6 mL
5 mM	0.49 mL	2.46 mL	4.92 mL
10 mM	0.25 mL	1.23 mL	2.46 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Sala et al (2013) CC4, a dimer of cytisine, is a selective partial agonist at α4β2/α6β2 nAChR with improved selectivity for tobacco smoking c Br.J.Pharmacol. 168 835 PMID: 22957729

Riganti et al (2005) Long-term exposure to the new nicotinic antagonist 1,2-bisN-cytisinylethane upregulates nicotinic receptor subtypes of SH-SY5Y human neuroblastoma cells. Br.J.Pharmacol. 146 1096 PMID: 16273122

Carbonnelle et al (2003) Nitrogen substitution modifies the activity of cytisine on neuronal nicotinic receptor subtypes. Eur.J.Pharmacol. 471 85 PMID: 12818695

Keywords: CC4, supplier, CC4, high, affinity, subtype, selective, partial, agonist, acetylcholine, nicotinic, receptors, alpha4beta2, a4b2, α4β2, alpha6beta3, a6b3, α6β3, Nicotinic, (a4b2), Receptors, Nicotinic, Receptors, (Other, Subtypes), Nicotinic, (a4b2), Receptors, Tocris Bioscience

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