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Tocris/AZD 7762 hydrochloride/5199/10/10 mg

价格: ¥2388.00 市场价: 3980.00

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货号: 5199/10

品牌: Tocris

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Description: Potent and selective ATP-competitive inhibitor of Chk1 and Chk2

Chemical Name: 3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-thiophenecarboxamide hydrochloride

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent and selective ATP-competitive inhibitor of Chk1 and Chk2 (IC₅₀ vales are 5 nM for both kinases); displays at least >10 fold selectivity over a panel of 164 kinases. Potentiates cytotoxicity of DNA-damaging agents. Active in vivo.

Licensing Information

Sold for research purposes under agreement from AstraZeneca

Compound Libraries

AZD 7762 hydrochloride is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox II. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	398.88
Formula	C₁₇H₁₉FN₄O₂S.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1246094-78-9
PubChem ID	56972142
InChI Key	WFZBLOIXZRZEDG-YDALLXLXSA-N
Smiles	FC1=CC=CC(C2=CC(NC(N)=O)=C(C(N[C@@H]3CNCCC3)=O)S2)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	39.89	100
	water	39.89	100

Preparing Stock Solutions

The following data is based on the product molecular weight 398.88. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.51 mL	12.54 mL	25.07 mL
5 mM	0.5 mL	2.51 mL	5.01 mL
10 mM	0.25 mL	1.25 mL	2.51 mL
50 mM	0.05 mL	0.25 mL	0.5 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Zabludoff et al (2008) AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies. Mol. Cancer Ther. 7 2955 PMID: 18790776

Morgan et al (2010) Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G₂ checkpoint and inhibition of homologous recombinational DNA repair. Cancer Res. 70 4972 PMID: 20501833

Keywords: AZD 7762 hydrochloride, supplier, AZD7762, hydrochloride, Potent, selective, ATP, competitive, inhibitors, inhibits, Chk1, Chk2, checkpoint, kinases, Checkpoint, Kinases, Checkpoint, Control, Kinases, Checkpoint, Kinases, Tocris Bioscience

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