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Tocris/JTE 607 dihydrochloride/5185/50/50 mg

价格: ¥11580.00 市场价: 19300.00

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货号: 5185/50

品牌: Tocris

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Description: Cytokine release inhibitor; anti-inflammatory

Chemical Name: N-[3,5-Dichloro-2-hydroxy-4-[2-(4-methyl-1-piperazinyl)ethoxy]benzoyl]-L-phenylalanine ethyl ester dihydrochloride

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Cytokine release inhibitor. Inhibits production of IL-1β, IL-8, IL-6, IL-10 and TNFα (IC₅₀ values are 5.9, 7.3, 8.8, 9.1 and 11.0 nM, respectively) from LPS-stimulated PBMCs. Reduces proinflammatory cytokine-release and attenuates lung permeability in a rat lung injury model. Induces apoptosis in leukemia cells in vitro and prolongs survival in a mouse leukemia model.

Compound Libraries

JTE 607 dihydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	597.36
Formula	C₂₅H₃₁Cl₂N₃O₅.2HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	188791-09-5
PubChem ID	9938544
InChI Key	JUJAUEQJEWIWCQ-FJSYBICCSA-N
Smiles	ClC1=C(OCCN2CCN(C)CC2)C(Cl)=CC(C(N[C@@H](CC3=CC=CC=C3)C(OCC)=O)=O)=C1O.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	59.74	100
	water	59.74	100

Preparing Stock Solutions

The following data is based on the product molecular weight 597.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.67 mL	8.37 mL	16.74 mL
5 mM	0.33 mL	1.67 mL	3.35 mL
10 mM	0.17 mL	0.84 mL	1.67 mL
50 mM	0.03 mL	0.17 mL	0.33 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Kakutani et al (1999) JTE-607, a novel inflammatory cytokine synthesis inhibitor without immunosuppression, protects from endotoxin shock in mice. Inflamm.Res. 48 461 PMID: 10493164

Jian (2004) JTE-607, a cytokine release blocker, attenuates acid aspiration-induced lung injury in rats. Eur.J.Pharmacol. 488 231 PMID: 15044056

Tajima et al (2010) JTE-607, a multiple cytokine production inhibitor, induces apoptosis accompanied by an increase in p21waf1/cip1 in acute myelogenous leukemia cells. Cancer Sci. 101 774 PMID: 20028380

Keywords: JTE 607 dihydrochloride, supplier, JTE607, dihydrochloride, cytokines, inhibitors, inhibits, TNFa, TNF-alpha, TNF-α, interleukins, IL-1beta, IL-1b, IL-1β, inflammation, anti-inflammatory, IL-6, IL-8, IL-10, apoptosis, Cytokines, Cytokines, Tocris Bioscience

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