TheDO11.10mousemodelisavaluabletoolforstudiesofTcellimmigration,immunoregulation,development,activation,andfunction.TheKJ1-26monoclonalantibodyreactswiththeTcellreceptor(TCR)expressedonlymphocytesoftheDO11.10transgenicmouseandtheTCRoftheBALB/c-derivedDO11.10andDO11.10.24Tcellhybridoma.TheDO11.10TCRisspecificforthechickenovalbumin(OVA)peptide(323-339)inthecontextofI-A[d]majorhistocompatibility(MHC)molecules.TransgenicDO11.10TcellsalsorecognizeOVApeptidefromjunglefowlandturkeyinthepresenceofA20-1.11,theH-2d-bearing,antigen-presentingBcelllymphoma.
Anti-DO11.10TCRpure-functionalgradeantibodyissuitedforfunctionalassays,forexample,blockingofantigenresponseofDO11.10Tcellhybridoma.