Fibroblast Growth Factors, FGFs, are a 22 member family ofproteins known to be involved in angiogenesis, wound healing andembryonic development. As a family, they bind to heparin andsignal through four receptor tyrosine kinases called, FGFR1, 2, 3and 4. Although the mechanism remains unclear, FGF-basic 154(known as FGF basic) is a critical component in keeping embryonicstem cells undifferentiated in cell culture systems. Recombinanthuman FGF-b 154 (FGF-2) is a non-glycosylated protein, containing154 amino acids and having a molecular mass of 17.2 kDa.
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