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Tocris/SRPIN340/5063/50/50 mg

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货号: 5063/50

品牌: Tocris

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Description: Selective SRPK1 inhibitor

Chemical Name: N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Selective serine arginine protein kinase (SRPK) 1 inhibitor (K_i = 0.89 μM). Inhibits SRPK2 at higher concentrations. Does not significantly inhibit other SRPKs such as CLK1 and CLK4, or other classes of SR kinases. Down-regulates expression of VEGF₁₆₅ but does not affect VEGF_165b expression.

Compound Libraries

SRPIN340 is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox II. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	349.35
Formula	C₁₈H₁₈F₃N₃O
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	218156-96-8
PubChem ID	2797577
InChI Key	DWFGGOFPIISJIT-UHFFFAOYSA-N
Smiles	O=C(C3=CC=NC=C3)NC1=C(N2CCCCC2)C=CC(C(F)(F)F)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	1eq. HCl	17.47	50
	DMSO	34.94	100
	ethanol	34.94	100

Preparing Stock Solutions

The following data is based on the product molecular weight 349.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.86 mL	14.31 mL	28.62 mL
5 mM	0.57 mL	2.86 mL	5.72 mL
10 mM	0.29 mL	1.43 mL	2.86 mL
50 mM	0.06 mL	0.29 mL	0.57 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Gammons et al (2013) SRPK1 inhibition modulates VEGF splicing to reduce pathological neovascularization in a rat model of retinopathy of prematurity. Invest.Ophthalmol.Vis.Sci. 54 5797 PMID: 23761094

Fukuhara et al (2006) Utilization of host SR protein kinases and RNA-splicing machinery during viral replication. Proc.Natl.Acad.Sci.USA 103 11329 PMID: 16840555

Oltean et al (2012) SRPK1 inhibition in vivo: modulation of VEGF splicing and potential treatment for multiple diseases. Biochem.Soc.Trans. 40 831 PMID: 22817743

Keywords: SRPIN340, supplier, SR, Protein, Kinase, inhibitors, Phosphorylation, Inhibitor, 340(SRPIN)340, Serine-Arginine-Rich, Protein, inhibits, SRPK1, SRPK2, Other, Kinases, Other, Kinases, Tocris Bioscience

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