Overview | Acell-permeablesymmetricalsulfonecompoundthatactsasapotentandATP-competitiveinhibitorofp38α/βMAPK(IC50=130and550nM,respectively),whileexihibitingmuchreducedactivity(≤23%inhibitionat1µM)againstp38γ/δ,ERK1/2,andJNK1/2/3.ShowntobemoreeffectivethanSB203850(Cat.Nos.559389,559395,and559398)ininhibitingLPS-inducedIL-1βreleasefromhPBMC(100%vs.50%inhibitionwith100µMrespectiveinhibitor). |