Tocris/ME 0328/5054/10/10 mg188bio精品生物—专注于实验室精品爆款的电商平台

BiologicalActivity

InhibitorofPARP-3(IC₅₀=0.89μM).DisplaysselectivityforPARP-3overPARP-1,PARP-2andotherARDTenzymes(IC₅₀valuesare6.3,10.8and>30μMrespectively).EnhancesCRISPR-Cas9-mediatedHER2mutationfrequency,resultinginincreasedreductioninproliferationofHER2-positivebreastcancercells.Cellpermeable.

CompoundLibraries

ME0328isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	321.37
Formula	C₁₉H₁₉N₃O₂
Storage	Storeat+4°C
Purity	≥98%(HPLC)
CASNumber	1445251-22-8
PubChemID	71571526
InChIKey	QIHBWVVVRYYYRO-ZDUSSCGKSA-N
Smiles	O=C2NC(CCC(N[C@@H](C)C3=CC=CC=C3)=O)=NC1=CC=CC=C12

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	32.14	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight321.37.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	3.11mL	15.56mL	31.12mL
5mM	0.62mL	3.11mL	6.22mL
10mM	0.31mL	1.56mL	3.11mL
50mM	0.06mL	0.31mL	0.62mL

MolarityCalculator

Calculatethemass,volume,orconcentrationrequiredforasolution.

ReconstitutionCalculator

Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.

Volume(toaddtovial)

DilutionCalculator

Calculatethedilutionrequiredtoprepareastocksolution.