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Tocris/LM11A 31 dihydrochloride/5046/50/50 mg

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货号: 5046/50

品牌: Tocris

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Description: Nonpeptide p75^NTR ligand; neuroprotective

Chemical Name: (2S,3S)-2-Amino-3-methyl-N-[2-(4-morpholinyl)ethyl]pentanamide dihydrochloride

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Nonpeptide p75^NTR ligand; blocks p75-mediated cell death and also increases proliferation and survival of hippocampal neural progenitors. Exhibits no effect on nerve growth factor (NGF) binding to TrkA. Prevents and reverses atrophy of cholinergic neurites, as well as reversing Alzheimer's Disease (AD) pathologies in mid- to late-stage AD mice models. Shown to promote functional recovery in a mouse model of spinal cord injury. Orally available and brain penetrant.

Technical Data

M. Wt	316.27
Formula	C₁₂H₂₅N₃O₂.2HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1243259-19-9
PubChem ID	91654620
InChI Key	LLIHJRRZJDEKLB-ULEGLUPFSA-N
Smiles	O=C([C@@H](N)[C@@H](C)CC)NCCN1CCOCC1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	31.63	100
	water	31.63	100

Preparing Stock Solutions

The following data is based on the product molecular weight 316.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.16 mL	15.81 mL	31.62 mL
5 mM	0.63 mL	3.16 mL	6.32 mL
10 mM	0.32 mL	1.58 mL	3.16 mL
50 mM	0.06 mL	0.32 mL	0.63 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Shi et al (2013) A small molecule P75NTR ligand protects neurogenesis after traumatic brain injury. Stem Cells [Epub ahead of print] PMID: 23940017

Massa et al (2006) Small, nonpeptide p75^NTR ligands induce survival signaling and inhibit proNGF-induced death. J.Neurosci. 26 5288 PMID: 6707781

Tep et al (2013) Oral administration of a small molecule targeted to block proNGF binding to p75 promotes myelin sparing and functional recovery after spinal cord injury. J.Neurosci. 33 397 PMID: 23303920

Simmons et al (2014) A small molecule p75^NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression. PLoS One 9 e102136 PMID: 25153701

Keywords: LM11A 31 dihydrochloride, supplier, LM11A31, dihydrochloride, p75NTR, ligands, selective, NGFR, nerve, growth, factor, receptors, Alzheimer's, Disease, neuroprotective, Trk, Receptors, Neuronal, Metabolism, Trk, Receptors, Tocris Bioscience

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