Tocris/Clozapine <em>N</em>-oxide/4936/10/10 mg188bio精品生物—专注于实验室精品爆款的电商平台

BiologicalActivity

Metaboliteofclozapine(Cat.No.0444).Activateshumanmuscarinicdesignerreceptors(DREADDs)invitro.SilenceshippocampalneuronsexpressinghM₄DREADDsinvitro.ActivatesG_s-linkedDREADDS-AgRPinmiceviaintracerebroventricular(i.c.v)injection.ShowntobeaP-glycoprotein(P-gp)effluxpumpsubstrate.OtherpotentandselectivehM₃DqDREADDagoNISTsavailable:DREADDagonist21(Cat.No.5548)andPerlapine(Cat.No.5549)

TechnicalData

M.Wt	342.82
Formula	C₁₈H₁₉ClN₄O
Storage	StoreatRT
Purity	≥99%(HPLC)
CASNumber	34233-69-7
PubChemID	2819
InChIKey	WYRDWWAASBTJLM-UHFFFAOYSA-N
Smiles	ClC(C=C3)=CC1=C3NC(C=CC=C2)=C2C(N4CC[N+](C)([O-])CC4)=N1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	6.86	20
	ethanol	3.43	10mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight342.82.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.92mL	14.58mL	29.17mL
5mM	0.58mL	2.92mL	5.83mL
10mM	0.29mL	1.46mL	2.92mL
50mM	0.06mL	0.29mL	0.58mL

MolarityCalculator

Calculatethemass,volume,orconcentrationrequiredforasolution.

ReconstitutionCalculator

Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.

Volume(toaddtovial)

DilutionCalculator

Calculatethedilutionrequiredtoprepareastocksolution.

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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Tocris/Clozapine N-oxide/4936/10/10 mg