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Tocris/PF 04885614/4916/50/50 mg

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货号: 4916/50

品牌: Tocris

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Description: Potent and selective Na_V1.8 channel blocker; active in vivo

Chemical Name: 1-Methyl-[1-[4-(4-trifluoromethoxy)phenyl]-imidazol-2-yl]-ethanamine

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent Na_V1.8 inhibitor (IC₅₀ = 53 nM for human Na_V1.8 channel). Exhibits selectivity for hNa_V1.8 over hNa_V1.6, hNa_V1.7, hNa_V1.1, hNa_V1.2 and hNa_V1.5 (IC₅₀ values are 4.2, 7.0, 11, 16 and 27 μM respectively). Orally bioavailable.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries

PF 04885614 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	285.26
Formula	C₁₃H₁₄F₃N₃O
Storage	Store at +4°C
Purity	≥98% (HPLC)
PubChem ID	65459349
InChI Key	AGORGFNWYAUYSU-UHFFFAOYSA-N
Smiles	CC(C)(N)C1=NC(C2=CC=C(OC(F)(F)F)C=C2)=CN1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	28.53	100
	ethanol	28.53	100

Preparing Stock Solutions

The following data is based on the product molecular weight 285.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.51 mL	17.53 mL	35.06 mL
5 mM	0.7 mL	3.51 mL	7.01 mL
10 mM	0.35 mL	1.75 mL	3.51 mL
50 mM	0.07 mL	0.35 mL	0.7 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Bagal et al (2013) Discovery of selective Na_V1.8 modulators for the treatment of chronic pain. Abstract. 4th RSC/SCI Symp. on Ion Channels as Ther. Targ PMID:

Keywords: PF 04885614, supplier, PF04885614, NaV1.8, voltage, gated, sodium, channel, inhibitors, inhibits, potent, selective, in, vivo, efficacy, antinociceptive, analgesic, Voltage-gated, Sodium, Channels, Voltage-gated, Sodium, Channels, Tocris Bioscience

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