Overview | Cellsrespondtotheirenvironmentinvariouswaysthroughintracellularsignaling.SignalingthroughReceptorTyrosinekinases(RTKs)oftenpromotesincreasedmetabolismandcellgrowth.ActivationofERK/MAPkinaseisoneofthekeyserine/threoninekinasesactivatedviaRTKsignaling,promotingincreasedactivityofp70S6kinase,MSK1,STATs,CREB,andmanyothersignalingintermediates.Othersignalingpathwaysinducedviastress(ex.heatshock/arsenitetreatment)ordeathreceptors(ex.TNFα)promotep38,JNK,andp53signalingpathways. |