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Tocris/(S)-Duloxetine hydrochloride/4798/10/10 mg

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货号: 4798/10

品牌: Tocris

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Description: Potent 5-HT and NA reuptake inhibitor; also blocks dopamine reuptake

Chemical Name: (+)-(S)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine hydrochloride

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

High affinity, competitive 5-HT and noradrenaline (NA) re-uptake inhibitor (K_i values are 8.5 and 45 nM for 5-HT and NA reuptake respectively in cortical synaptosomes; IC₅₀ values are 28 and 46 nM for 5-HT and NA reuptake respectively in rat hippocampal slices). Also blocks dopamine reuptake (K_i = 300 nM in striatal synaptosomes). Exhibits antidepressant and anxiolytic effects. Orally bioavailable.

Compound Libraries

(S)-Duloxetine hydrochloride is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	333.88
Formula	C₁₈H₁₉NOS.HCl
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	136434-34-9
PubChem ID	60834
InChI Key	BFFSMCNJSOPUAY-LMOVPXPDSA-N
Smiles	CNCC[C@@H](C3=CC=CS3)OC2=CC=CC1=CC=CC=C12.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	33.39	100
	water	3.34	10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 333.88. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3 mL	14.98 mL	29.95 mL
5 mM	0.6 mL	3 mL	5.99 mL
10 mM	0.3 mL	1.5 mL	3 mL
50 mM	0.06 mL	0.3 mL	0.6 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Wong et al (1988) LY227942, an inhibitor of serotonin and norepinephrine uptake: biochemical pharmacology of a potential antidepressant drug. Life Sci. 43 2049 PMID: 2850421

Kasamo et al (1996) Blockade of the serotonin and norepinephrine uptake processes by duloxetine: in vitro and in vivo studies in the rat brain. J.Pharmacol.Exp.Ther. 277 278 PMID: 8613930

Keywords: (S)-Duloxetine hydrochloride, supplier, SNRI, 5-HT, NE, norepinephrine, noradrenaline, reuptake, inhibitors, inhibits, potent, high, affinity, antidepressants, anxiolytics, orally, available, 5-HT, Transporters, Adrenergic, Transporters, Dopamine, Transporters, 5-HT, Transporters, Tocris Bioscience

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