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Tocris/NS 11021/4788/10/10 mg

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货号: 4788/10

品牌: Tocris

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Description: Activator of BK_Ca (K_Ca1.1) channels

Chemical Name: N'-[3,5-Bis(trifluoromethyl)phenyl]-N-[4-bromo-2-(2H-tetrazol-5-yl-phenyl]thiourea

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Activator of large-conductance Ca²⁺-activated potassium channels (BK_Ca, K_Ca1.1). Exhibits no modulatory effect on a variety of K⁺ (K_V), Na⁺ and Ca²⁺ currents at concentrations <10 μM. Alters gating kinetics, but does not affect single channel conductance. Shown to bind BK_Ca in open and closed conformations; thought to bind the α subunit.

Compound Libraries

NS 11021 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	511.24
Formula	C₁₆H₉BrF₆N₆S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	956014-19-0
PubChem ID	24825677
InChI Key	MDKAFDIKYQMOMF-UHFFFAOYSA-N
Smiles	BrC1=CC(C2=NN=NN2)=C(NC(NC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)=S)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	51.12	100
	ethanol	51.12	100

Preparing Stock Solutions

The following data is based on the product molecular weight 511.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.96 mL	9.78 mL	19.56 mL
5 mM	0.39 mL	1.96 mL	3.91 mL
10 mM	0.2 mL	0.98 mL	1.96 mL
50 mM	0.04 mL	0.2 mL	0.39 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Layne et al (2009) BK channel activation by NS11021 decreases excitability and contractility of urinary bladder smooth muscle. Am.J.Physiol.Regul.Integr.Comp.Physiol. 298 R378 PMID: 19923353

Bentzen et al (2007) The small molecule NS11021 is a potent and specific activator of Ca²⁺-activated big-conductance K⁺ channels. Mol.Pharmacol. 72 1033 PMID: 17636045

Kun et al (2009) NS11021, a novel opener of large-conductance Ca²⁺-activated K⁺ channels, enhances erectile responses in rats. Br.J.Pharmacol. 158 1465 PMID: 19845682

Keywords: NS 11021, supplier, NS11021, NS_11021, BKCa, KCa1.1, large-conductance, Ca2+-activated, Ca2+-dependent, calcium, potassium, K+, channels, activators, activates, openers, opens, Ca2+-Activated, Potassium, Channels, Ca2+-Activated, Potassium, Channels, Tocris Bioscience

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