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SelectiveKv7.1(KCNQ1)potassiumchannelactivator(EC50=260nM).Exhibits>100-foldselectivityversusKCNQ2,KCNQ4andhERGpotassiumchannels.AugmentsIKscurrentofculturedhumancardiomyocytesandshortensactionpotentialduration.
ML277isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Thefollowingdataisbasedontheproductmolecularweight471.59.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Referencesarepublicationsthatsupporttheproducts'biologicalactivity.
Mattmannetal(2012)Identificationof(R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide,ML277,asanovel,potentandselectiveKv7.1(KCNQ1)potassiumchannelactivator.Bioorg.Med.Chem.Lett.225936PMID:22910039
Yuetal(2013)DynamicsubunitstoichiometryconfersaprogressivecontinuumofpharmacologicalsensitivitybyKCNQpotassiumchannels.Proc.Natl.Acad.Sci.U.S.A.1108732PMID:23650380
Keywords:ML277,supplier,ML277,kv7.1,channel,activators,activates,kv7.1,channel,KCNQ1,selective,IKs,currents,long,QT,syndrome,LQTS,Voltage-Gated,Potassium,Channels,Voltage-Gated,Potassium,Channels,TocrisBioscience
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