Description:InhibitorofHedgehog(Hh)signaling;bindsdirectlytoSmo
ChemicalName:(2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11a,11b-hexadecahydro-3-hydroxy-3',6',10,11b-tetramethyl-Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-11(1H)-one
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
InhibitorofHedgehogsignaling(IC50=500-700nM);bindsdirectlytoSmoothened(Smo).InhibitstheresponseoftargettissuestoSonichedgehogsignaling,possIBLyviathesterolsensingdomainofPatched.Teratogenic.
TechnicalData
| M.Wt | 425.6 |
| Formula | C27H39NO3 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 469-59-0 |
| PubChemID | 10098 |
| InChIKey | CLEXYFLHGFJONT-DNMILWOZSA-N |
| Smiles | O[C@H](C2)CC[C@@]1(C)C2=CC[C@]([C@@](CC[C@@]54O[C@@](C[C@H](C)CN6)([H])[C@]6([H])[C@H]5C)([H])C3=[C@@]4C)([H])[C@@]([H])1C3=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM |
|---|
| Solubility |
|---|
| DMSO | 8.51 | 20 |
| ethanol | 21.28 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight425.6.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|
| 1mM | 2.35mL | 11.75mL | 23.5mL |
| 5mM | 0.47mL | 2.35mL | 4.7mL |
| 10mM | 0.23mL | 1.17mL | 2.35mL |
| 50mM | 0.05mL | 0.23mL | 0.47mL |
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
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