ChemicalName:(3
S,5a
R,10b
S,11a
S)-2,3,5a,6,10b,11-hexahydro-3-(hydroxymethyl)-10b-(3-[(1
S,4
S)-3-[[4-(hydroxymethyl)-5,7-dimethyl-6,8-dioxo-2,3-dithia-5,7-diaz
ABIcyclo[2.2.2]oct-1-yl)methyl]-1
H-indol-1-yl]-2-methyl-3,11a-epidithio-11a
H-pyrazino[1',2':1,5]pyrrolo[2,3-
b]indole-1,4-dione
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
TargetstheCH1domainofCBP/p300;inhibitsinteractionofHIF-1α,HIF-2αandSTAT2withCBP/p300.Attenuateshypoxia-inducedgeneexpressioninvitroandinvivo;rADIosensitizeshumanHT1080fibrosarcomacellsinvitro.
TechnicalData
| M.Wt | 710.87 |
| Formula | C31H30N6O6S4 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1403-36-7 |
| PubChemID | 90488965 |
| InChIKey | ZRZWBWPDBOVIGQ-KIDIPURZSA-N |
| Smiles | CN(C([C@@](CO)7N(C)C3=O)=O)[C@]3(SS7)CC2=CN([C@@]5(C[C@@](SS9)6C8=O)C4=CC=CC=C4N[C@@]([H])5N6C([C@@](CO)9N8C)=O)C1=CC=CC=C12 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight710.87.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|
| 1mM | 1.41mL | 7.03mL | 14.07mL |
| 5mM | 0.28mL | 1.41mL | 2.81mL |
| 10mM | 0.14mL | 0.7mL | 1.41mL |
| 50mM | 0.03mL | 0.14mL | 0.28mL |
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
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