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HistonedemethylaseKDM2/7subfamilyinhibitor(IC50valuesare0.55,1.5and2.1μMforPHF8,KDM2AandKDM7Arespectively).Exhibits≥60-foldselectivityforKDM2/7demethylasesoverotherhistonedemethylasesand2-oxoglurateoxygenases(IC50>100μM).
DaminozideisalsoofferedaspartoftheTocriscreenPlusandTocriscreenEpigeneticsToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Thefollowingdataisbasedontheproductmolecularweight160.17.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Referencesarepublicationsthatsupporttheproducts'biologicalactivity.
Roseetal(2012)PlantgrowthregulatordaminozideisaselectiveinhibitorofhumanKDM2/7histonedemethylases.J.Med.Chem.556639PMID:22724510
Keywords:Daminozide,supplier,jmjc,kdm2/7,kdm2a,kdm7a,phf8,histone,demethylases,inhibits,inhibitors,selective,epigenetics,Histone,Demethylases,Histone,Demethylases,TocrisBioscience
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