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Tocris/Zolmitriptan/4657/50/50 mg

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货号: 4657/50

品牌: Tocris

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Description: Potent 5-HT_1B/1D/1F agonist

Chemical Name: (4S)-4-((3-(2-(Dimethylamino)ethyl)-1H-indol-5-yl)methyl)-2-oxazolidinone

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent 5-HT_1B/_1D/_1F agonist (K_i values are 0.63, 5.01 and 63.09 nM for h5-HT_1D, h5-HT_1B and h5-HT_1F receptors respectively). Inhibits trigeminal nerve stimulation-mediated neurogenic plasma protein extravasation in guinea pigs; blocks long excitatory postsynaptic potentials (EPSPs) in a rat model of spinal cord injury.

Compound Libraries

Zolmitriptan is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	287.36
Formula	C₁₆H₂₁N₃O₂
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	139264-17-8
PubChem ID	60857
InChI Key	ULSDMUVEXKOYBU-ZDUSSCGKSA-N
Smiles	CN(C)CCC2=CNC1=CC=C(C[C@H](N3)COC3=O)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	28.74	100
	ethanol	28.74	100

Preparing Stock Solutions

The following data is based on the product molecular weight 287.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.48 mL	17.4 mL	34.8 mL
5 mM	0.7 mL	3.48 mL	6.96 mL
10 mM	0.35 mL	1.74 mL	3.48 mL
50 mM	0.07 mL	0.35 mL	0.7 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Murray et al (2011) Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors. J.Neurophysiol. 106 925 PMID: 21653728

Pauwels et al (1997) How efficacious are 5-HT1B/D receptor ligands: an answer from GTP gamma S binding studies with stably transfected C6-glial cell lines. Neuropharmacology 36 499 PMID: 9225275

Martin et al (1997) Receptor specificity and trigemino-vascular inhibitory actions of a novel 5-HT1B/1D receptor partial agonist, 311C90 (zolmitriptan). Br.J.Pharmacol. 121 157 PMID: 9154322

Keywords: Zolmitriptan, supplier, 5ht, 5-ht, serotonergics, 5ht1B, 5ht1D, 5ht1F, potent, agonists, excitatory, postsynaptic, potentials, migraine, neurogenic, plasma, protein, extravasation, 5-HT1B, Receptors, 5-HT1D, Receptors, 5-HT1F, Receptors, 5-HT1D, Receptors, Tocris Bioscience

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