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Tocris/SAHA/4652/50/50 mg

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货号: 4652/50

品牌: Tocris

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Description: Class I and II HDAC inhibitor

Alternative Names: Vorinostat

Chemical Name: N-Hydroxy-N'-phenyloctanediamide

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Inhibits Class I and II histone deacetylases (HDACs); induces accumulation of acetylated histones H2A, H2B, H3 and H4 in transformed cultured cells. Suppresses cell growth in a range of cancer cell lines; induces apoptosis in cutaneous T cell lymphoma cells in vitro. Activates autophagy.

Compound Libraries

SAHA is also offered as part of the Tocriscreen Plus, Tocriscreen Epigenetics Toolbox, Tocriscreen Library of FDA-Approved Compounds and Tocriscreen Stem Cell Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	264.32
Formula	C₁₄H₂₀N₂O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	149647-78-9
PubChem ID	5311
InChI Key	WAEXFXRVDQXREF-UHFFFAOYSA-N
Smiles	O=C(CCCCCCC(NO)=O)NC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	26.43	100
	ethanol	1.32	5mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 264.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.78 mL	18.92 mL	37.83 mL
5 mM	0.76 mL	3.78 mL	7.57 mL
10 mM	0.38 mL	1.89 mL	3.78 mL
50 mM	0.08 mL	0.38 mL	0.76 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Butler et al (2000) Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses the growth of prostate cancer cells in vitro and in vivo. Cancer Res. 60 5165 PMID: 11016644

Leoni et al (2002) The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines. Proc.Natl.Acad.Sci.U.S.A 99 2995 PMID: 11867742

Marks and Breslow (2007) Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug. Nat.Biotechnol. 25 84 PMID: 17211407

Huangfu et al (2008) Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nat.Biotechnol. 26 795 PMID: 18568017

Galluzzi et al (2017) Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov. PMID: 28529316

Keywords: SAHA, supplier, histone, deacetylases, HDACs, inhibits, inhibitors, Class, I, Class, II, vorinostat, anticancer, antiproliferatives, epigenetics, proapoptotic, Vorinostat, Histone, Deacetylases, Autophagy, Histone, Deacetylases, Tocris Bioscience

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