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Tocris/I-BET 151 dihydrochloride/4650/50/50 mg

价格: ¥11100.00 市场价: 18500.00

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货号: 4650/50

品牌: Tocris

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Description:BETbromodomaininhibitor;alsopromotesdifferentiationofhiPSCsintomegakaryocytes

ChemicalName:7-(3,5-Dimethyl-4-isoxazolyl)-1,3-dihydroxy-8-methoxy-1-[(1R)-1-(2-pyridinyl)ethyl]-2H-imidazo[4,5-c]quinolin-2-onedihydrochloride

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

BETbromodomaininhibitor;blocksrecruitmentofBETtochromatin.InducesapoptosisandG₀/G₁cellcyclearrestinMLL-fusionleukemiccelllinesinvitro(IC₅₀valuesare15,26,120and192nMforNOMO1,MV4;11,MOLM13andRS4;11celllinesrespectively);reducesBCL2expressioninNOMO1cells.ImprovessurvivalintworodentmodelsofMLL-fusionleukemiainvivo.EnhancesdifferentiationofhumaniPSCintomegakaryocytes.

LicensingInformation

SoldforresearchpurposesunderagreementfromGlaxoSmithKline

ExternalPortalInformation

Chemicalprobes.orgisaportalthatoffersindependentguidanceontheselectionand/orapplicationofsmallmoleculesforresearch.TheuseofI-BET151isreviewedonthechemicalprobeswebsite.

CompoundLibraries

I-BET151dihydrochlorideisalsoofferedaspartoftheTocriscreenPlusandTocriscreenEpigeneticsToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	488.37
Formula	C₂₃H₂₁N₅O₃.2HCl
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	1883545-47-8
PubChemID	170320
InChIKey	IQOJZZHRYSSFJM-UHFFFAOYSA-N
Smiles	O=C(N3[C@H](C)C4=NC=CC=C4)NC2=C3C1=CC(OC)=C(C5=C(C)ON=C5C)C=C1N=C2.Cl.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	41.54	100
	ethanol	41.54	100
	water	48.84	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight488.37.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.05mL	10.24mL	20.48mL
5mM	0.41mL	2.05mL	4.1mL
10mM	0.2mL	1.02mL	2.05mL
50mM	0.04mL	0.2mL	0.41mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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