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Tocris/MKT 077/4621/50/50 mg

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货号: 4621/50

品牌: Tocris

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Description: Binds mot-2; selectively cytotoxic in cancer cells

Chemical Name: 1-Ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-pyridinium chloride

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Occupies mortalin-2 (mot-2), a member of the Hsp70 family, at its p53 binding site and enables p53 translocation to the nucleus. Selectively cytotoxic; causes growth arrest of cancer cells in culture. Also inhibits telomerase activity and cross-links F-actin.

Compound Libraries

MKT 077 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	432
Formula	C₂₁H₂₂ClN₃OS₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	147366-41-4
PubChem ID	3037933
InChI Key	VSKYOTRJSLYFHX-UXJRWBAGSA-M
Smiles	CN(C1=CC=CC=C1S2)/C2=C4/C(N(CC)/C(S4)=CC3=CC=CC=[N+]3CC)=O.[Cl-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	21.6	50
	water	21.6	50

Preparing Stock Solutions

The following data is based on the product molecular weight 432. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.31 mL	11.57 mL	23.15 mL
5 mM	0.46 mL	2.31 mL	4.63 mL
10 mM	0.23 mL	1.16 mL	2.31 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Wadhwa et al (2000) Selective toxicity of MKT-077 to cancer cells is mediated by its binding to the hsp70 family protein mot-2 and reactivation of p53 function. Cancer Res. 60 6818 PMID: 11156371

Wadhwa et al (2002) Rhodacyanine dye MKT-077 inhibits in vitro telomerase activity but has no detectable effects on telomerase activity in vivo. Cancer Res. 62 4434 PMID: 12154051

Tikoo et al (1999) Treatment of Ras-induced cancers by the F-actin cappers tensin and chaetoglobosin K, in combination with the caspase-1 inhibitor N1445. Cancer J.Sci.Am. 5 293 PMID: 10526670

Patury et al (2009) Pharmacological targeting of the Hsp70 chaperone. Curr.Top.Med.Chem. 9 1337 PMID: 19860737

Keywords: MKT 077, supplier, MKT077, heat, shock, proteins, 70, Hsp70, Hsps, inhibitors, inhibits, telomerase, inhibitors, inhibits, F-actin, cross-linkers, Hsp70, Hsp70, Tocris Bioscience

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