Description:PotentandselectiveBKCa(KCa1.1)channelblocker
ChemicalName:2R,3S,3aR,4aS,4bS,6aR,7S,7dR,8R,9aR,14bS,14cR,16aS)-12-chloro-3,3a,6a,8,9,9a,10,11,14,14b,14c,15,16,16a-tetradecahydro-14b,14c,17,17-tetramethyl-10-methylene-2-(1-methylethenyl)-7,8-(epoxymethano)-2H,6H-cyclobuta[5,6]benz[1,2-e]oxireno[4',4'a]-1-benzopyrano[5',6':6,7]indeno[1,2-b]indole-3,4b,7d(5H,7H)-triol
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
PotentandselectiveblockerofBKCa(KCa1.1)channels(IC50valuesare6.4and64.4nMforBKCachannelscontainingαsubunitsonly,andthosecontainingαandβ1respectively).DisplaysnoeffectonnativedelayedrectifierK+andKATPcurrents,orclonedKV1.5channels.BlocksBKCachannelsinbothinside-outandcell-attachedpatches.Showntoenhancesmoothmusclecontractioninvitroandincreasetotalperipheralresistanceinvivo.
TechnicalData
| M.Wt | 634.2 |
| Formula | C37H44ClNO6 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 12627-35-9 |
| PubChemID | 6610243 |
| InChIKey | JDUWHZOLEDOQSR-JKPSMKLGSA-N |
| Smiles | O[C@H]9[C@@H]([C@](C)=C)O[C@@]([C@@]%108[C@@H]9O%10)([H])CC[C@]([C@@]8(O)CC7)(C)[C@@]([C@]7([H])[C@@H]4OC(C)(C)[C@]([H])5C6)(C)C3=C4C1=C(N3)C=C(Cl)C2=C1[C@@]5(O)[C@@]6([H])C(C2)=C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM |
|---|
| Solubility |
|---|
| DMSO | 6.34 | 10 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight634.2.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|
| 1mM | 1.58mL | 7.88mL | 15.77mL |
| 5mM | 0.32mL | 1.58mL | 3.15mL |
| 10mM | 0.16mL | 0.79mL | 1.58mL |
| 50mM | 0.03mL | 0.16mL | 0.32mL |
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
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