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Tocris/Olmesartan/4616/50/50 mg

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货号: 4616/50

品牌: Tocris

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Description: Potent AT₁ antagonist; metabolite of Olmesartan medoxomil (Cat. No. 4620)

Chemical Name: 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent angiotensin II type I (AT₁) receptor antagonist (IC₅₀ = 6.7 nM at hAT₁ receptors). Improves cognitive function in a mouse model of hypertension- and hyperlipidemia-associated cognitive decline; ameliorates arterial stiffness in a rat model of chronic renal failure. Metabolite of Olmesartan medoxomil (Cat. No. 4620).

Compound Libraries

Olmesartan is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	446.5
Formula	C₂₄H₂₆N₆O₃
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	144689-24-7
PubChem ID	158781
InChI Key	VTRAEEWXHOVJFV-UHFFFAOYSA-N
Smiles	CCCC1=NC(C(C)(C)O)=C(C(O)=O)N1CC2=CC=C(C3=CC=CC=C3C4=NN=NN4)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	8.93	20

Preparing Stock Solutions

The following data is based on the product molecular weight 446.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.24 mL	11.2 mL	22.4 mL
5 mM	0.45 mL	2.24 mL	4.48 mL
10 mM	0.22 mL	1.12 mL	2.24 mL
50 mM	0.04 mL	0.22 mL	0.45 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Mogi et al (2007) Inhibition of cognitive decline in mice fed a high-salt and cholesterol diet by the angiotensin receptor blocker, olmesartan. Neuropharmacology 53 899 PMID: 18028965

Chuang et al (2012) Effects of olmesartan on arterial stiffness in rats with chronic renal failure. Cardiovasc.Diabetol. 11 66 PMID: 22694778

Ojima et al (2011) In vitro antagonistic properties of a new angiotensin type 1 receptor blocker, azilsartan, in receptor binding and function studies. J.Pharmacol.Exp.Ther. 336 801 PMID: 21123673

Keywords: Olmesartan, supplier, rnh, 6270, rnh6270, olmetec, benicar, potent, antagonists, angiotensin, II, receptors, blockers, ARBs, AT1, antihypertensive, Angiotensin, AT1, Receptors, Angiotensin, AT1, Receptors, Tocris Bioscience

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