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Tocris/NS 8593 hydrochloride/4597/50/50 mg

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货号: 4597/50

品牌: Tocris

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Description: Selective K_Ca2 (SK) channel negative modulator; inhibits SK currents

Chemical Name: N-[(1R)-1,2,3,4-Tetrahydro-1-naphthalenyl]-1H-benzimidazol-2-amine hydrochloride

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Selective K_Ca2 (SK) channel negative modulator; inhibits SK channel currents (K_d values are 0.42, 0.6 and 0.73 μM for SK1, SK2 and SK3 respectively at 0.5 μM Ca²⁺). Exhibits selectivity for SK channels over K_Ca1.1 (BK), K_Ca3.1 (IK), K_v, Na_v and Ca_v channels. Inhibits afterhyperpolarization in hippocampal slices.

Compound Libraries

NS 8593 hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	299.8
Formula	C₁₇H₁₇N₃.HCl
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	875755-24-1
PubChem ID	71311765
InChI Key	VWEKCDTXUUPBNA-PFEQFJNWSA-N
Smiles	C12=CC=CC=C1N=C(N[C@H]3C(C=CC=C4)=C4CCC3)N2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	29.98	100
	ethanol	6	20

Preparing Stock Solutions

The following data is based on the product molecular weight 299.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.34 mL	16.68 mL	33.36 mL
5 mM	0.67 mL	3.34 mL	6.67 mL
10 mM	0.33 mL	1.67 mL	3.34 mL
50 mM	0.07 mL	0.33 mL	0.67 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Strøbaek et al (2006) Inhibitory gating modulation of small conductance Ca²⁺-activated K⁺ channels by the synthetic compound (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphtylamine (NS8593) reduces afterhyperpolarizing current in hip Mol.Pharmacol. 70 1771 PMID: 16926279

Sørensen (2008) Synthesis and structure-activity relationship studies of 2-(N-substituted)-aminobenzimidazoles as potent negative gating modulators of small conductance Ca²⁺-activated K⁺ channels. J.Med.Chem. 51 7625 PMID: 18998663

Jenkins et al (2011) Negative gating modulation by (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine (NS8593) depends on residues in the inner pore vestibule: pharmacological evidence of deep-pore gating of K_Ca2 channels. Mol.Pharmacol. 79 899 PMID: 21363929

Keywords: NS 8593 hydrochloride, supplier, NS8593, hydrochloride, selective, Kca2, SK, small, channels, conductance, calcium, ca2+, activated, potassium, K+, modulators, inhibits, inhibitors, Ca2+-Activated, Potassium, Channels, Ca2+-Activated, Potassium, Channels, Tocris Bioscience

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