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Tocris/SNS 314 mesylate/4584/50/50 mg

价格: ¥11100.00 市场价: 18500.00

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货号: 4584/50

品牌: Tocris

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Description: Potent pan-Aurora kinase inhibitor

Chemical Name: N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea methanesulfonate

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent, ATP-competitive Aurora kinase inhibitor (IC₅₀ values are 3, 9 and 31 nM for Aurora C, A and B, respectively). Exhibits both in vitro and in vivo activity against human cancer cell lines and tumor xenograft models. Displays additive antiproliferative effects in combination with chemotherapeutics such as carboplatin (Cat. No. 2626), gemcitabine (Cat. No. 3259) and 5-fluorouracil (Cat. No. 3257).

Compound Libraries

SNS 314 mesylate is also offered as part of the Tocriscreen Plus, Tocriscreen Kinase Inhibitor Toolbox II and Tocriscreen Epigenetics Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	527.04
Formula	C₁₈H₁₅ClN₆OS₂.CH₃SO₃H
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1146618-41-8
PubChem ID	24995523
InChI Key	FYCODPVDEFFWSR-UHFFFAOYSA-N
Smiles	O=C(NC4=CC(Cl)=CC=C4)NC3=NC=C(S3)CCNC1=NC=NC2=C1SC=C2.CS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	52.7	100

Preparing Stock Solutions

The following data is based on the product molecular weight 527.04. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.9 mL	9.49 mL	18.97 mL
5 mM	0.38 mL	1.9 mL	3.79 mL
10 mM	0.19 mL	0.95 mL	1.9 mL
50 mM	0.04 mL	0.19 mL	0.38 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Arbitrario et al (2010) SNS-314, a pan-Aurora kinase inhibitor, shows potent and anti-tumor activity and dosing flexibility in vivo. Cancer Chemother. Pharmacol. 65 707 PMID: 19649632

VanderPorten et al (2009) The Aurora kinase inhibitor SNS-314 shows broad therapeutic potential with chemotherapeutics and synergy with microtubule-targeted agents in a colon carcinoma model. Mol.Cancer Ther. 8 930 PMID: 19372566

Oslob et al (2008) Discovery of a potent and selective Aurora kinase inhibitor. Bioorg.Med.Chem.Lett. 18 4880 PMID: 18678489

Keywords: SNS 314 mesylate, supplier, SNS314, mesylate, aurora, kinases, inhibitors, inhibits, potent, antiproliferatives, Aurora, Kinases, Aurora, Kinases, Tocris Bioscience

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